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Vimentin Monoclonal Antibody [hVimentin] (CPAB0495)

SKU:
CPAB0495
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
hVimentin
Applications:
IP
WB
ELISA
IHC
$792

Description

system_update_alt Datasheet

Vimentin Monoclonal Antibody [hVimentin] (CPAB0495)

The Vimentin Polyclonal Antibody (CPAB0495) is an essential tool for researchers studying vimentin, a key cytoskeletal protein involved in maintaining cell shape and integrity. This antibody, produced in rabbits, exhibits high reactivity with Vimentin in human samples and is validated for use in Western blot applications. By binding to the Vimentin protein, this antibody enables precise detection and analysis in a variety of cell types, making it an ideal choice for studies in cell biology, cancer research, and more.Vimentin is a versatile protein with roles in cell migration, adhesion, and signaling, making it a crucial player in processes like wound healing and tissue remodeling.

Dysregulation of Vimentin expression is associated with various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions, highlighting its importance in pathological pathways. By utilizing the Vimentin Polyclonal Antibody, researchers can gain valuable insights into Vimentin's functions and potential implications in disease development, paving the way for innovative therapeutic approaches.

Product Name:Vimentin Antibody
Product Sku:CPAB0495
Size:500μg
Host Species:mouse
Immunogen:Purified Human Vimentin.
Clone:hVimentin.
Reactivity:Other bodies
Applications:Immuneprecipitation, Western Blot, ELISA, Immunohistochemistry
Purification Method:Ion exchange column.
Isotype:IgG1
Background:Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
Synonyms:
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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