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Vimentin Monoclonal Antibody, Biotin [hVimentin] (CPAB0496)

SKU:
CPAB0496
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG1
Clone:
hVimentin
Applications:
IHC
€809
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Description

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Vimentin Monoclonal Antibody, Biotin [hVimentin] (CPAB0496)

The Vimentin Antibody (Biotin) (CPAB0496) is a powerful tool for research involving vimentin, a type III intermediate filament protein that plays a key role in maintaining cell shape, integrity, and motility. This polyclonal antibody, produced in rabbits, exhibits high reactivity with human samples and is suitable for use in various applications such as immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry.Vimentin is a well-known marker for mesenchymal cells and has been implicated in processes such as epithelial-mesenchymal transition (EMT) during cancer progression and wound healing.

The ability to detect and visualize vimentin expression in different cell types and tissues makes this antibody a valuable tool for studies in cell biology, cancer research, and regenerative medicine.By targeting vimentin, researchers can gain deeper insights into the role of this protein in various physiological and pathological conditions, including metastasis, fibrosis, and tissue repair. This antibody is a reliable option for scientists looking to explore vimentin's functions and potential therapeutic applications in different disease contexts.

Product Name:Vimentin Antibody, Biotin
Product Sku:CPAB0496
Size:500μg
Host Species:mouse
Immunogen:Purified Human Vimentin.
Clone:hVimentin.
Reactivity:Other bodies
Applications:Immunohistochemistry
Purification Method:Ion exchange column.
Isotype:IgG1
Background:Vimentin expression in human malignant glioma cells depends on cellular density, algorithms of drug delivery and chemo/radio treatment. Vimentin and detyrosinated microtubules provide structural support for the extensive microtentacles observed in detached tumor cells and a mechanism to promote successful metastatic spread. Primary colorectal carcinomas display aberrant expression of vimentin, and have activated Notch and TGFbeta signaling pathways. Vimentin is a strong arterial substrate for transglutaminases. Transglutaminase-mediated vimentin dimerization results in a novel unifying pathway by which vasodilatory and remodeling responses may be regulated. Ablation of vimentin expression inhibits migration and invasion of colon and breast cancer cell lines.
Synonyms:
Storage Buffer:In lyophilized form, for long periods, store at 4°C in a dry environment. After reconstitution, if not intended for use within a month, aliquot and store at -20°C.

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