The Vimentin Polyclonal Antibody (CAB11952) is a valuable research tool designed for studying vimentin, an important intermediate filament protein involved in cell structure and signaling. This antibody, produced in rabbits, exhibits high reactivity with vimentin in human samples and is validated for use in Western blot applications. By targeting the vimentin protein, researchers can detect and analyze its expression in various cell types, making it a versatile tool for studies in cell biology, cancer research, and tissue development.Vimentin is a key structural protein that plays a crucial role in maintaining cell shape, integrity, and motility. It is involved in numerous cellular processes, including cell migration, adhesion, and signaling pathways.
Dysregulation of vimentin expression has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative conditions. Therefore, understanding the role of vimentin in these pathological conditions is essential for developing targeted therapies and diagnostic tools.Overall, the Vimentin Polyclonal Antibody (CAB11952) provides researchers with a reliable tool for investigating the function and expression of vimentin in a variety of research areas. Its high specificity and sensitivity make it a valuable asset for advancing our understanding of vimentin biology and its implications in human health and disease.
This gene encodes a type III intermediate filament protein. Intermediate filaments, along with microtubules and actin microfilaments, make up the cytoskeleton. The encoded protein is responsible for maintaining cell shape and integrity of the cytoplasm, and stabilizing cytoskeletal interactions. This protein is involved in neuritogenesis and cholesterol transport and functions as an organizer of a number of other critical proteins involved in cell attachment, migration, and signaling. Bacterial and viral pathogens have been shown to attach to this protein on the host cell surface. Mutations in this gene are associated with congenital cataracts in human patients.
Purification Method:
Affinity purification
Gene ID:
7431
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using [KD Validated] Vimentin Rabbit pAb (CAB11952) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
