null

VHL Monoclonal Antibody [P52A11AT] (CPAB0512)

SKU:
CPAB0512
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
P52A11AT
Applications:
WB
ELISA
€149
Frequently bought together:

Description

system_update_alt Datasheet

VHL Monoclonal Antibody [P52A11AT] (CPAB0512)

The VHL Polyclonal Antibody (CPAB0512) is a valuable tool for researchers studying the von Hippel-Lindau (VHL) gene and its role in cancer and tumor development. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the VHL protein, this antibody allows for the detection and analysis of VHL expression in various cell types, making it an essential component in cancer research and molecular biology studies.The VHL gene is known for its tumor suppressor function and its involvement in the regulation of hypoxia-inducible factors (HIFs), which play a key role in the adaptation of cells to low oxygen levels.

Mutations in the VHL gene have been linked to the development of various cancers, including clear cell renal cell carcinoma and pheochromocytoma. Understanding the expression and function of VHL is vital for unraveling the mechanisms underlying these diseases and identifying potential therapeutic targets.Overall, the VHL Polyclonal Antibody (CPAB0512) serves as a valuable tool for researchers investigating the role of the VHL gene in cancer and tumor biology. Its high specificity and sensitivity make it a reliable choice for studying VHL expression and function in a variety of experimental settings.

Product Name:VHL Antibody
Product Sku:CPAB0512
Size:5μg
Host Species:Mouse
Immunogen:Anti-human VHL mAb is derived from hybridization of mouse SP2/O myeloma cells with spleen cells from BALB/c mice immunized with recombinant human VHL amino acids 1-154 purified from Ecoli.
Clone:P52A11AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:VHL antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:Von Hippel-Lindau disease is a dominant inherited syndrome characterized by the predisposition to develop various kinds of benign and malignant tumors, including clear cell renal carcinomas, pheochromocytomas and hemangioblastomas of the central nervous system and retina. VHL syndrome is caused by germline mutation in the VHL tumor suppressor, and VHL tumors are associated with loss or mutation of the remaining wild-type allele. VHL has two domains: a roughly 100-residue NH2-terminal domain rich in  sheet (-domain) and a smaller -helical domain (-domain), held together by two linkers and a polar interface. VHL protein is also involved in the degradation of hypoxia-inducible factor (HIF).
Synonyms:Von Hippel-Lindau disease tumor suppressor, pVHL, Protein G7, VHL, RCA1, VHL1, HRCA1.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

Related Products