The VGF Polyclonal Antibody (PAC020852) is a vital tool for researchers studying the protein VGF, which is known for its role in regulating mood and energy balance. This antibody, produced using rabbits, exhibits high reactivity towards human samples and is recommended for use in Western blot applications. By targeting the VGF protein, this antibody enables precise detection and analysis in various cell types, making it ideal for investigations in neuroscience and metabolic disorders.
VGF is a neuropeptide that has been linked to various physiological processes, including stress responses, appetite regulation, and neuroprotection. Its involvement in mood disorders, such as depression and anxiety, as well as metabolic conditions like obesity, makes it a promising target for pharmaceutical research. Understanding the function of VGF is essential for developing novel treatments that target the brain-gut axis and metabolic pathways affected by this protein.
The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20852(VGF Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Gel: 8%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20852(VGF Antibody) at dilution 1/500 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute.
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20852(VGF Antibody) at dilution 1/45, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known.
Synonyms:
VGF nerve growth factor inducible
UniProt Protein Function:
VGF: May be involved in the regulation of cell-cell interactions or in synatogenesis during the maturation of the nervous system.
UniProt Protein Details:
Protein type:Secreted, signal peptide; Secreted
Chromosomal Location of Human Ortholog: 7q22.1
Cellular Component: extracellular space; transport vesicle; cytoplasmic vesicle
Biological Process: response to dietary excess; generation of precursor metabolites and energy; response to cAMP; ovarian follicle development; insulin secretion; sexual reproduction; defense response to bacterium; response to cold; glucose homeostasis; response to insulin stimulus
NCBI Summary:
This gene is specifically expressed in a subpopulation of neuroendocrine cells, and is upregulated by nerve growth factor. The structural organization of this gene is similar to that of the rat gene, and both the translated and the untranslated regions show a high degree of sequence similarity to the rat gene. The encoded secretory protein also shares similarities with the secretogranin/chromogranin family, however, its exact function is not known. [provided by RefSeq, Jul 2008]
