The VEGF Receptor-1 Rabbit Monoclonal Antibody (CAB19132) is a cutting-edge tool for researchers studying vascular endothelial growth factor receptor 1 (VEGFR1), a key player in angiogenesis and vascular development. This antibody, developed and validated for use in various research applications, exhibits high specificity and sensitivity for detection of VEGFR1 in human samples.By specifically binding to VEGFR1, this antibody enables precise detection and analysis of the receptor in different cell types and tissues. Its use is particularly valuable in studies related to angiogenesis, cancer biology, and cardiovascular research, where VEGFR1 signaling pathways play a crucial role.
Understanding the mechanisms of VEGFR1 activation and signaling is essential for the development of targeted therapies for diseases such as cancer, diabetic retinopathy, and cardiovascular disorders. The VEGF Receptor-1 Rabbit Monoclonal Antibody offers researchers a reliable tool for investigating the role of VEGFR1 in these disease contexts and advancing our understanding of angiogenesis and vascular biology.
Product Name:
VEGFR1 Rabbit Monoclonal Antibody
SKU:
CAB19132
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VEGFR1 (P17948).
Cell membrane, Cytoplasm, Endosome, Secreted, Single-pass type I membrane protein.
Calculated MW:
151kDa
Observed MW:
180kDa
This gene encodes a member of the vascular endothelial growth factor receptor (VEGFR) family. VEGFR family members are receptor tyrosine kinases (RTKs) which contain an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and a tyrosine kinase (TK) domain within the cytoplasmic domain. This protein binds to VEGFR-A, VEGFR-B and placental growth factor and plays an important role in angiogenesis and vasculogenesis. Expression of this receptor is found in vascular endothelial cells, placental trophoblast cells and peripheral blood monocytes. Multiple transcript variants encoding different isoforms have been found for this gene. Isoforms include a full-length transmembrane receptor isoform and shortened, soluble isoforms. The soluble isoforms are associated with the onset of pre-eclampsia.
Purification Method:
Affinity purification
Gene ID:
2321
Clone Number:
ARC0363
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using VEGFR1 antibody (CAB19132) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
