The VDAC3 Polyclonal Antibody (CAB10544) is specially designed for research involving VDAC3, a mitochondrial protein involved in cell metabolism and apoptosis regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the VDAC3 protein, this antibody allows for accurate detection and analysis in various cell types, making it an ideal tool for studies in the fields of mitochondrial biology and cell death mechanisms.VDAC3, also known as voltage-dependent anion-selective channel protein 3, plays a crucial role in regulating the flux of molecules across the mitochondrial outer membrane, controlling processes such as ATP production and apoptosis.
Its significance in cell metabolism and survival mechanisms makes it a valuable target for research into diseases like cancer, neurodegenerative disorders, and metabolic syndromes. Understanding the functions of VDAC3 is essential for developing treatments that target mitochondrial function and apoptosis in these pathological conditions.
Product Name:
VDAC3 Rabbit Polyclonal Antibody
SKU:
CAB10544
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-283 of human VDAC3 (NP_005653.3).
This gene encodes a voltage-dependent anion channel (VDAC), and belongs to the mitochondrial porin family. VDACs are small, integral membrane proteins that traverse the outer mitochondrial membrane and conduct ATP and other small metabolites. They are known to bind several kinases of intermediary metabolism, thought to be involved in translocation of adenine nucleotides, and are hypothesized to form part of the mitochondrial permeability transition pore, which results in the release of cytochrome c at the onset of apoptotic cell death. Alternatively transcript variants encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
7419
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse heart, using VDAC3 Rabbit pAb (CAB10544) at 1:500 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Enhanced Kit (AbGn00021).Exposure time: 180s.
