The VDAC2 Polyclonal Antibody (CAB16294) is a valuable tool for researchers studying the Voltage-Dependent Anion Channel 2 (VDAC2), a key protein involved in mitochondrial function and apoptosis. This antibody, raised in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the VDAC2 protein, this antibody allows for the detection and analysis of VDAC2 in various cell types, making it an ideal choice for studies in mitochondrial biology, cell death pathways, and cancer research.VDAC2 is a critical component of the mitochondrial permeability transition pore and plays a crucial role in regulating the exchange of metabolites and ions between the mitochondria and the cytosol.
Dysregulation of VDAC2 has been implicated in various diseases, including cancer and neurodegenerative disorders, making it an important target for further investigation. Understanding the function and regulation of VDAC2 can provide valuable insights into the mechanisms underlying these diseases and may lead to the development of novel therapeutic strategies targeting mitochondrial dysfunction.
Product Name:
VDAC2 Polyclonal Antibody
SKU:
CAB16294
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-309 of human VDAC2 (NP_001171712.1).
This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
7417
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using VDAC2 Rabbit pAb (CAB16294) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
