The VDAC1 Polyclonal Antibody (CAB15735) is specifically designed for research involving the Voltage-dependent anion-selective channel protein 1 (VDAC1), a key component of the mitochondrial outer membrane that plays a crucial role in regulating mitochondrial functions. This antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunohistochemistry. It binds specifically to VDAC1 protein, allowing for accurate detection and analysis in a variety of cell types.VDAC1 is involved in various cellular processes including apoptosis, metabolism, and calcium ion transport, making it an important target for research in fields like cell biology, neurology, and cancer research.
Understanding the function of VDAC1 can provide insights into mitochondrial dysfunction and its role in disease pathogenesis.Researchers studying mitochondrial biology, apoptosis, and energy metabolism will find the VDAC1 Polyclonal Antibody (CAB15735) to be a valuable tool in their investigations. Its high specificity and sensitivity make it an ideal choice for studying the function and regulation of VDAC1 in different biological contexts.
Product Name:
VDAC1 / Porin Polyclonal Antibody
SKU:
CAB15735
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC1 / Porin (NP_003365.1).
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.
Purification Method:
Affinity purification
Gene ID:
7416
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using VDAC1 / Porin Rabbit pAb (CAB15735) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
