The VDAC1 Polyclonal Antibody (CAB0810) is a valuable tool for research involving VDAC1, a protein located in the mitochondrial outer membrane that plays a crucial role in regulating metabolic and apoptotic processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and is validated for use in Western blot applications. By specifically binding to VDAC1, the antibody enables precise detection and analysis of this protein in various cell types, making it ideal for studies in mitochondrial biology, apoptosis, and cancer research.VDAC1, also known as Voltage-Dependent Anion Channel 1, is essential for mitochondrial function and cell survival.
Its involvement in the regulation of energy metabolism, apoptosis, and cell signaling pathways makes it a key player in numerous cellular processes. Research on VDAC1 is important for understanding the mechanisms underlying various diseases such as cancer, neurodegenerative disorders, and metabolic diseases. By studying the function and regulation of VDAC1, researchers can explore potential therapeutic targets for these conditions and gain insights into mitochondrial dysfunction.
Product Name:
VDAC1/Porin Rabbit Polyclonal Antibody
SKU:
CAB0810
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-283 of human VDAC1 / Porin (NP_003365.1).
This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.
Purification Method:
Affinity purification
Gene ID:
7416
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using VDAC1 / Porin Rabbit pAb (CAB0810) at 1:400 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
