The VDAC1 Polyclonal Antibody (PAC062091) is a valuable tool for researchers investigating the role of the Voltage-Dependent Anion Channel 1 (VDAC1) in cellular function. VDAC1 is a key player in regulating the transport of ions and metabolites across the mitochondrial outer membrane, essential for cell metabolism and apoptosis.This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the VDAC1 protein, researchers can accurately detect and analyze its expression in various cell types, providing insights into mitochondrial function and its implications in diseases like cancer, neurodegenerative disorders, and metabolic conditions.
With its ability to target VDAC1, a critical component of mitochondrial physiology, the PAC062091 antibody offers a unique opportunity to study the role of this protein in cellular processes and disease pathology. Its application in research on mitochondrial dysfunction and its consequences opens up possibilities for therapeutic interventions targeting VDAC1-dependent pathways.
Antibody Name:
VDAC1 Antibody (PACO62091)
Antibody SKU:
PACO62091
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Arabidopsis thaliana
Immunogen:
Recombinant Arabidopsis thaliana Mitochondrial outer membrane protein porin 1 protein (2-276AA)
Western Blot. Positive WB detected in: Arabidopsis thaliana leaf tissue, Apium graveolens leaf tissue, Spinacia oleracea leaf tissue, Glycine max leaf tissue, Capsicum annuum leaf tissue, Solanum tuberosum leaf tissue, Vicia faba leaf tissue, Ipomoea batatas leaf tissue. All lanes: VDAC1 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa.
Background:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance.
Synonyms:
Mitochondrial outer membrane protein porin 1 (Voltage-dependent anion-selective channel protein 1) (AtVDAC1) (VDAC-1), VDAC1
UniProt Protein Function:
Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance.
UniProt Protein Details:
NCBI Summary:
Encodes a voltage-dependent anion channel (VDAC: AT3G01280/VDAC1, AT5G67500/VDAC2, AT5G15090/VDAC3, AT5G57490/VDAC4, AT5G15090/VDAC5). VDACs are reported to be porin-type, beta-barrel diffusion pores. They are prominently localized in the outer mitochondrial membrane and are involved in metabolite exchange between the organelle and the cytosol.
