VDAC1 Antibody (PACO62091)
- SKU:
- PACO62091
- Product Type:
- Antibody
- Reactivity:
- Plant - Arabidopsis
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Frequently bought together:
Description
VDAC1 Antibody (PACO62091)
The VDAC1 Polyclonal Antibody (PAC062091) is a valuable tool for researchers investigating the role of the Voltage-Dependent Anion Channel 1 (VDAC1) in cellular function. VDAC1 is a key player in regulating the transport of ions and metabolites across the mitochondrial outer membrane, essential for cell metabolism and apoptosis.This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the VDAC1 protein, researchers can accurately detect and analyze its expression in various cell types, providing insights into mitochondrial function and its implications in diseases like cancer, neurodegenerative disorders, and metabolic conditions.
With its ability to target VDAC1, a critical component of mitochondrial physiology, the PAC062091 antibody offers a unique opportunity to study the role of this protein in cellular processes and disease pathology. Its application in research on mitochondrial dysfunction and its consequences opens up possibilities for therapeutic interventions targeting VDAC1-dependent pathways.
| Antibody Name: | VDAC1 Antibody (PACO62091) |
| Antibody SKU: | PACO62091 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000 |
| Species Reactivity: | Arabidopsis thaliana |
| Immunogen: | Recombinant Arabidopsis thaliana Mitochondrial outer membrane protein porin 1 protein (2-276AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot. Positive WB detected in: Arabidopsis thaliana leaf tissue, Apium graveolens leaf tissue, Spinacia oleracea leaf tissue, Glycine max leaf tissue, Capsicum annuum leaf tissue, Solanum tuberosum leaf tissue, Vicia faba leaf tissue, Ipomoea batatas leaf tissue. All lanes: VDAC1 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa. |
| Background: | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (By similarity). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance. |
| Synonyms: | Mitochondrial outer membrane protein porin 1 (Voltage-dependent anion-selective channel protein 1) (AtVDAC1) (VDAC-1), VDAC1 |
| UniProt Protein Function: | Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules. The channel adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective (). Involved in plant development at reproductive stage, is important for pollen development and may regulate hydrogen peroxide generation during disease resistance. |
| UniProt Protein Details: | |
| NCBI Summary: | Encodes a voltage-dependent anion channel (VDAC: AT3G01280/VDAC1, AT5G67500/VDAC2, AT5G15090/VDAC3, AT5G57490/VDAC4, AT5G15090/VDAC5). VDACs are reported to be porin-type, beta-barrel diffusion pores. They are prominently localized in the outer mitochondrial membrane and are involved in metabolite exchange between the organelle and the cytosol. |
| UniProt Code: | Q9SRH5 |
| NCBI GenInfo Identifier: | 15232074 |
| NCBI Gene ID: | 820914 |
| NCBI Accession: | NP_186777.1 |
| UniProt Secondary Accession: | Q9SRH5 |
| UniProt Related Accession: | Q9SRH5 |
| Molecular Weight: | Predicted Molecular Mass: 60.6kDaAccurate Molecular Mass: 61kDa as determined by SDS-PAGE reducing conditions. |
| NCBI Full Name: | voltage dependent anion channel 1 |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | VDAC1Â Â |
| NCBI Official Synonym Symbols: | 5076; ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1; ATVDAC1; T22N4.9; T22N4_9; VDAC1; voltage dependent anion channel 1Â Â |
| NCBI Protein Information: | voltage dependent anion channel 1 |
| UniProt Protein Name: | Mitochondrial outer membrane protein porin 1 |
| UniProt Synonym Protein Names: | Voltage-dependent anion-selective channel protein 1; AtVDAC1; VDAC-1 |
| Protein Family: | Voltage-dependent anion-selective channel protein |
| UniProt Gene Name: | VDAC1Â Â |
| UniProt Entry Name: | VDAC1_ARATH |
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