The VCP Rabbit Monoclonal Antibody is a cutting-edge research tool designed for the study of Valosin-Containing Protein (VCP), a key player in various cellular processes including protein degradation and DNA damage repair. Raised in rabbits, this antibody offers high specificity and sensitivity for detecting VCP in human samples, making it an essential tool for researchers in cell biology and cancer research.VCP, also known as p97, is a AAA+ ATPase enzyme involved in multiple cellular pathways, including endoplasmic reticulum-associated degradation (ERAD) and autophagy. Dysregulation of VCP has been linked to various diseases, including neurodegenerative disorders and cancer.
Understanding the role of VCP in these conditions is essential for the development of targeted therapies and diagnostic tools.The VCP Rabbit Monoclonal Antibody is validated for use in Western blotting, immunofluorescence, and immunohistochemistry applications, providing researchers with versatile options for their experiments. With its high reactivity and reliability, this antibody is an invaluable asset for scientists investigating the complex functions of VCP in health and disease.
Product Name:
VCP Rabbit Monoclonal Antibody
SKU:
CAB1402
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VCP (P55072).
This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients.
Purification Method:
Affinity purification
Gene ID:
7415
Clone Number:
ARC0728
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using VCP Rabbit mAb (CAB1402) at 1：1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
