The VCP Polyclonal Antibody (CAB13368) is specifically designed for research involving VCP, also known as valosin-containing protein. This cell surface molecule plays a crucial role in various cellular processes, including protein degradation and quality control. The antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.By binding to the VCP protein, this antibody enables accurate detection and analysis in a variety of cell types. This makes it an essential tool for researchers studying cellular mechanisms, protein homeostasis, and diseases related to VCP dysfunction.
With its ability to specifically target VCP, this antibody is valuable for investigations in areas such as neurodegenerative disorders, cancer, and rare genetic diseases.Understanding the function and regulation of VCP is key to unraveling its role in health and disease. By utilizing the VCP Polyclonal Antibody (CAB13368), researchers can delve deeper into the complexities of cellular processes and potentially uncover new therapeutic targets for a range of conditions.
Product Name:
VCP Rabbit Polyclonal Antibody
SKU:
CAB13368
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 647-806 of human VCP (NP_009057.1).
This gene encodes a member of the AAA ATPase family of proteins. The encoded protein plays a role in protein degradation, intracellular membrane fusion, DNA repair and replication, regulation of the cell cycle, and activation of the NF-kappa B pathway. This protein forms a homohexameric complex that interacts with a variety of cofactors and extracts ubiquitinated proteins from lipid membranes or protein complexes. Mutations in this gene cause IBMPFD (inclusion body myopathy with paget disease of bone and frontotemporal dementia), ALS (amyotrophic lateral sclerosis) and Charcot-Marie-Tooth disease in human patients.
Purification Method:
Affinity purification
Gene ID:
7415
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using VCP Rabbit pAb (CAB13368) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
