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vcp Antibody (PACO61870)

SKU:
PACO61870
Product Type:
Antibody
Reactivity:
Fish - Zebrafish
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€339
Frequently bought together:

Description

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vcp Antibody (PACO61870)

The VCP Polyclonal Antibody (PAC061870) is a valuable tool for research involving Valosin-Containing Protein (VCP), a key player in cellular protein homeostasis and regulation. This antibody, generated in rabbits, is highly specific and reacts strongly with human samples. Validated for use in Western blot applications, it binds to the VCP protein, enabling accurate detection and analysis in a variety of cell types.VCP, also known as p97, is involved in diverse cellular processes such as protein degradation, DNA repair, and cell cycle regulation. Dysregulation of VCP has been implicated in various diseases including neurodegenerative disorders and cancer.

Studying the function of VCP is crucial for unraveling its roles in these conditions and potentially identifying new therapeutic targets.With its high reactivity and specificity, the VCP Polyclonal Antibody is an essential tool for researchers in areas such as cell biology, oncology, and neurology. By enabling precise detection and analysis of VCP, this antibody aids in advancing our understanding of the intricate mechanisms underlying cellular function and disease pathology.

Antibody Name:vcp Antibody (PACO61870)
Antibody SKU:PACO61870
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB
Recommended Dilutions:ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:Zebrafish
Immunogen:Recombinant Zebrafish Transitional endoplasmic reticulum ATPase protein (704-806AA)
Form:Liquid
Storage Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method:>95%, Protein G purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageWestern Blot. Positive WB detected in: Zebrafish tissue, Zebrafish brain tissue, Zebrafish heart tissue, Zebrafish eye tissue. All lanes: vcp antibody at 1.8µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 90 kDa. Observed band size: 90 kDa.
Background:Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (By similarity). Enhances cell cycle progression and inhibits apoptosis at low temperatures. Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (By similarity). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (By similarity). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (By similarity).
Synonyms:Transitional endoplasmic reticulum ATPase (TER ATPase) (EC 3.6.4.6) (Protein CDC48) (Valosin-containing protein) (VCP), vcp, cdc48
UniProt Protein Function:Necessary for the fragmentation of Golgi stacks during mitosis and for their reassembly after mitosis. Involved in the formation of the nuclear envelope, and of the transitional endoplasmic reticulum (tER). The transfer of membranes from the endoplasmic reticulum to the Golgi apparatus occurs via 50-70 nm transition vesicles which derive from part-rough, part-smooth transitional elements of the endoplasmic reticulum (tER). Vesicle budding from the tER is an ATP-dependent process. Also involved in DNA damage response: recruited to double-strand breaks (DSBs) sites and promotes the recruitment of tp53bp1 at DNA damage sites (). Enhances cell cycle progression and inhibits apoptosis at low temperatures (PubMed:12914916). Essential for the maturation of ubiquitin-containing autophagosomes and the clearance of ubiquitinated protein by autophagy (). Acts as a negative regulator of type I interferon production by promoting ubiquitination of ddx58/rig-i (). May play a role in the ubiquitin-dependent sorting of membrane proteins to lysosomes where they undergo degradation (). May more particularly play a role in caveolins sorting in cells (). By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway ().
UniProt Protein Details:
NCBI Summary:
UniProt Code:Q7ZU99
NCBI GenInfo Identifier:41393119
NCBI Gene ID:327197
NCBI Accession:NP_958889.1
UniProt Secondary Accession:Q7ZU99,Q76KA4
UniProt Related Accession:Q7ZU99
Molecular Weight:
NCBI Full Name:transitional endoplasmic reticulum ATPase
NCBI Synonym Full Names:valosin containing protein
NCBI Official Symbol:vcp  
NCBI Official Synonym Symbols:CDC48; wu:fd16d05; wu:fj63d11  
NCBI Protein Information:transitional endoplasmic reticulum ATPase
UniProt Protein Name:Transitional endoplasmic reticulum ATPase
UniProt Synonym Protein Names:Protein CDC48
Protein Family:VCP-like ATPase
UniProt Gene Name:vcp  
UniProt Entry Name:
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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