The VCL Polyclonal Antibody (CAB14193) is an essential tool for researchers studying VCL, a protein involved in cell adhesion and migration. This antibody is generated in rabbits and has been validated for use in Western blot applications, demonstrating high reactivity with human samples.VCL, also known as vinculin, plays a crucial role in maintaining cell-cell and cell-matrix interactions, making it a key player in processes such as cell motility and tissue development. By specifically binding to the VCL protein, this antibody enables accurate detection and analysis in a variety of cell types, making it ideal for studies in cell biology and cancer research.
The function of VCL in cell adhesion and migration makes it a target of interest in various diseases, including cancer metastasis and cardiovascular diseases. By investigating the role of VCL in these pathological conditions, researchers can gain a better understanding of disease mechanisms and potentially identify new therapeutic targets.Overall, the VCL Polyclonal Antibody (CAB14193) offers researchers a reliable tool for studying the function of VCL in cellular processes and disease pathogenesis. Its high specificity and sensitivity make it a valuable asset in advancing research in the fields of cell biology and oncology.
Product Name:
Vinculin Rabbit Polyclonal Antibody
SKU:
CAB14193
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 751-850 of human Vinculin (NP_054706.1).
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
Purification Method:
Affinity purification
Gene ID:
7414
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Vinculin antibody (CAB14193) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
