The VCAM1 Polyclonal Antibody (CAB0279) is a valuable tool for researchers studying VCAM1, a cell adhesion molecule involved in immune responses and inflammatory processes. Produced in rabbits, this antibody exhibits high reactivity with human samples and is validated for use in Western blot applications. By binding to the VCAM1 protein, this antibody facilitates the detection and analysis of VCAM1 expression in a variety of cell types, making it an ideal choice for studies in immunology and cancer research.VCAM1, also known as vascular cell adhesion molecule 1, plays a crucial role in leukocyte adhesion and recruitment during inflammation.
Its involvement in various pathological conditions, such as atherosclerosis and autoimmune diseases, highlights its potential as a therapeutic target. Research on VCAM1 is vital for understanding the mechanisms underlying inflammatory responses and developing targeted therapies for immune-related disorders.Overall, the VCAM1 Polyclonal Antibody (CAB0279) offers researchers a reliable tool for investigating the role of VCAM1 in immune regulation and inflammatory processes, ultimately contributing to advancements in disease research and therapeutic development.
Product Name:
VCAM1 Rabbit Polyclonal Antibody
SKU:
CAB0279
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 300-400 of human VCAM1 (NP_001069.1).
This gene is a member of the Ig superfamily and encodes a cell surface sialoglycoprotein expressed by cytokine-activated endothelium. This type I membrane protein mediates leukocyte-endothelial cell adhesion and signal transduction, and may play a role in the development of artherosclerosis and rheumatoid arthritis. Three alternatively spliced transcripts encoding different isoforms have been described for this gene.
Purification Method:
Affinity purification
Gene ID:
7412
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of lysates from HUVEC cells, using VCAM1 Rabbit pAb (CAB0279) at 1:500 dilution.HUVEC cells were treated by Human Tumor Necrosis Factor-α (hTNF-α) (10 ng/ml) for 16 hoursSecondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
