UniProt Protein Function: | VAX2: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. Belongs to the EMX homeobox family.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 2p13Biological Process: ectoderm development; forebrain development |
UniProt Protein Details: | |
NCBI Summary: | This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq, Sep 2008] |
UniProt Code: | Q9UIW0 |
NCBI GenInfo Identifier: | 20532295 |
NCBI Gene ID: | 25806 |
NCBI Accession: | Q9UIW0.1 |
UniProt Secondary Accession: | Q9UIW0,Q53Y33 |
UniProt Related Accession: | Q9UIW0 |
Molecular Weight: | 30,874 Da |
NCBI Full Name: | Ventral anterior homeobox 2 |
NCBI Synonym Full Names: | ventral anterior homeobox 2 |
NCBI Official Symbol: | VAX2Â Â |
NCBI Official Synonym Symbols: | DRES93Â Â |
NCBI Protein Information: | ventral anterior homeobox 2 |
UniProt Protein Name: | Ventral anterior homeobox 2 |
UniProt Synonym Protein Names: | |
Protein Family: | Ventral anterior homeobox |
UniProt Gene Name: | VAX2Â Â |
UniProt Entry Name: | VAX2_HUMAN |