The VAX2 Polyclonal Antibody (PAC061706) is a powerful tool for researchers studying VAX2, a transcription factor essential for eye development. This antibody, produced in rabbits, demonstrates high specificity and sensitivity in detecting VAX2 protein in human samples, making it suitable for use in Western blot applications. By binding to VAX2, this antibody enables precise visualization and analysis of VAX2 expression in various cell types, allowing researchers to explore its role in eye development and diseases affecting the visual system.
VAX2 is a key regulator of eye formation and has been implicated in conditions such as anophthalmia, microphthalmia, and other congenital eye abnormalities. Its critical functions in the development of the eye make it a promising target for research aimed at understanding the molecular mechanisms underlying these conditions. By investigating the activity of VAX2, researchers can gain valuable insights into eye development and potentially identify new therapeutic strategies for treating eye disorders.
Antibody Name:
VAX2 Antibody (PACO61706)
Antibody SKU:
PACO61706
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:5000
Species Reactivity:
Human
Immunogen:
Recombinant Human Ventral anterior homeobox 2protein (1-74AA)
Western Blot. Positive WB detected in: Hela whole cell lysate, A549 whole cell lysate. All lanes: VAX2 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 31 kDa. Observed band size: 31 kDa.
Background:
Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle (By similarity). May be a regulator of axial polarization in the retina.
Synonyms:
Ventral anterior homeobox 2, VAX2
UniProt Protein Function:
VAX2: Transcription factor that may function in dorsoventral specification of the forebrain. Regulates the expression of Wnt signaling antagonists including the expression of a truncated TCF7L2 isoform that cannot bind CTNNB1 and acts therefore as a potent dominant-negative Wnt antagonist. Plays a crucial role in eye development and, in particular, in the specification of the ventral optic vesicle. May be a regulator of axial polarization in the retina. Belongs to the EMX homeobox family.Protein type: Transcription factor; DNA-bindingChromosomal Location of Human Ortholog: 2p13Biological Process: ectoderm development; forebrain development
UniProt Protein Details:
NCBI Summary:
This gene encodes a homeobox protein and is almost exclusively expressed in the ventral portion of the retina during development. In mouse studies, this gene was found to be required for the correct formation of the optic fissure and other aspects of retinal development. [provided by RefSeq, Sep 2008]
