VASP Rabbit Polyclonal Antibody (CAB0166)
- SKU:
- CAB0166
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Product Name: | VASP Rabbit Polyclonal Antibody |
SKU: | CAB0166 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 150-250 of human VASP (NP_003361.1). |
Sequence: | EHIE RRVS NAGG PPAP PAGG PPPP PGPP PPPG PPPP PGLP PSGV PAAA HGAG GGPP PAPP LPAA QGPG GGGA GAPG LAAA IAGA KLRK VSKQ EEAS GGPT A |
Tested Applications: | WB ELISA |
Recommended Dilution: | WB,1:500 - 1:1000 |
Synonyms: | VASP |
Positive Sample: | HEL |
Conjugate: | Unconjugated |
Cellular Localization: | Cell junction, Cell projection, Cytoplasm, cytoskeleton, filopodium membrane, focal adhesion, lamellipodium membrane, tight junction. |
Calculated MW: | 40kDa |
Observed MW: | 50kDa |
Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG.
Purification Method: | Affinity purification |
Gene ID: | 7408 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3. |