The VASH2 Polyclonal Antibody (PAC017415) is a valuable tool for research into VASH2, a protein involved in angiogenesis and vascular homeostasis. This antibody, produced in rabbits, demonstrates high reactivity with human samples and is validated for use in Western blot applications. By binding specifically to the VASH2 protein, this antibody enables researchers to detect and analyze VASH2 expression in various cell types, making it an ideal choice for studies in vascular biology and cancer research.
VASH2, also known as vasohibin-2, is a key player in the regulation of blood vessel formation and maintenance. Its role in angiogenesis and vascular remodeling makes it a promising target for investigating diseases such as cancer, cardiovascular disorders, and inflammatory conditions. Understanding the function of VASH2 is crucial for developing therapies that target angiogenesis and vascular dysfunction in these pathological states.
Antibody Name:
VASH2 Antibody (PACO17415)
Antibody SKU:
PACO17415
Size:
50ul
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:5000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Full length fusion protein
Form:
Liquid
Storage Buffer:
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:
Antigen affinity purification
Clonality:
Polyclonal
Isotype:
IgG
Conjugate:
Non-conjugated
Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Hela and 293T cell, Primary antibody: PACO17415(VASH2 Antibody) at dilution 1/450 dilution, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds.
Background:
Vasohibin-2, also known as VASH2, is a 355 amino acid, protein belonging to the Vasohibin family. Expressed in various embryonic organs, Vasohibin-2 can be detected during embryonic weeks six through twelve and is found in vessels of 20-week embryonic organs as well as in endothelial cells of neonatal large vessels. Induced by VEGF, Vasohibin-2 is an angiogenesis inhibitor and interferes with the proliferation, migration and network formation by endothelial cells.
Synonyms:
vasohibin 2
UniProt Protein Function:
VASH2: Angiogenesis inhibitor. Inhibits network formation by endothelial cells. Belongs to the vasohibin family. 5 isoforms of the human protein are produced by alternative splicing.Chromosomal Location of Human Ortholog: 1q32.3Cellular Component: cytoplasmBiological Process: positive regulation of angiogenesis; positive regulation of endothelial cell proliferation
