The VAPB Polyclonal Antibody (CAB5363) is specifically designed for research involving VAPB, a protein that plays a crucial role in the endoplasmic reticulum (ER) and the cell membrane interaction. The antibody, raised in rabbits, is highly reactive with human samples and is validated for use in various applications such as Western blot and immunofluorescence.VAPB is a key player in cellular processes such as lipid transport, ER stress response, and membrane trafficking. Dysregulation of VAPB has been linked to neurodegenerative diseases like amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA).
Therefore, understanding the function and regulation of VAPB is essential for gaining insights into these diseases and developing potential therapeutic strategies.Researchers in the fields of neuroscience, cell biology, and molecular biology will find this antibody valuable for studying the role of VAPB in cellular physiology and disease pathology. Its high reactivity and specificity make it a reliable tool for detecting and analyzing VAPB expression in various cell types, providing new avenues for research and discovery in these areas.
Product Name:
VAPB Rabbit Polyclonal Antibody
SKU:
CAB5363
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 10-222 of human VAPB (NP_004729.1).
Endoplasmic reticulum membrane, Single-pass type IV membrane protein.
Calculated MW:
27kDa
Observed MW:
27kDa
The protein encoded by this gene is a type IV membrane protein found in plasma and intracellular vesicle membranes. The encoded protein is found as a homodimer and as a heterodimer with VAPA. This protein also can interact with VAMP1 and VAMP2 and may be involved in vesicle trafficking.
Purification Method:
Affinity purification
Gene ID:
9217
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using VAPB Rabbit pAb (CAB5363) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
