The VAMP3 Polyclonal Antibody (CAB7457) is a valuable tool for researchers studying vesicle-associated membrane protein 3 (VAMP3), a key protein involved in regulating membrane fusion events in cells. This antibody is produced in rabbits and exhibits high reactivity with human samples, making it ideal for Western blot applications.VAMP3 is known to play a crucial role in intracellular membrane trafficking and exocytosis, particularly in the context of neurotransmitter release and membrane recycling. By targeting VAMP3 with this antibody, researchers can effectively detect and analyze the protein in various cell types, allowing for a deeper understanding of its functional roles in cellular processes.
The implications of VAMP3 in cellular physiology and pathology make it a valuable target for research in fields such as neurobiology, endocrinology, and cell biology. By using the VAMP3 Polyclonal Antibody, scientists can further investigate the mechanisms underlying membrane fusion events and potentially identify novel therapeutic targets for conditions related to aberrant vesicle trafficking.
Product Name:
VAMP3/Cellubrevin Rabbit Polyclonal Antibody
SKU:
CAB7457
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-80 of human VAMP3/Cellubrevin (NP_004772.1).
Cell junction, Membrane, Single-pass type IV membrane protein, synapse, synaptosome.
Calculated MW:
11kDa
Observed MW:
15kDa
Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Because of its high homology to other known VAMPs, its broad tissue distribution, and its subcellular localization, the protein encoded by this gene was shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
Purification Method:
Affinity purification
Gene ID:
9341
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using VAMP3/Cellubrevin antibody (CAB7457) at 1:1000 dilution._Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution._Lysates/proteins: 25μg per lane._Blocking buffer: 3% nonfat dry milk in TBST._Detection: ECL Enhanced Kit (AbGn00021)._Exposure time: 5s.
