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VAMP3 Monoclonal Antibody [Pk2A2AT] (CPAB0535)

SKU:
CPAB0535
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Universal
Host Species:
Mouse
Isotype:
IgG2b
Clone:
Pk2A2AT
Applications:
WB
ELISA
€149
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Description

system_update_alt Datasheet

VAMP3 Monoclonal Antibody [Pk2A2AT] (CPAB0535)

The VAMP3 Polyclonal Antibody (CPAB0535) is a valuable tool for researchers studying VAMP3, a protein involved in intracellular membrane trafficking and vesicle fusion processes. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By targeting the VAMP3 protein, this antibody enables the visualization and analysis of VAMP3 in various cell types, making it suitable for investigations in cell biology and neurobiology.VAMP3, also known as cellubrevin, plays a critical role in regulating membrane fusion events within cells, including neurotransmitter release at synapses and the transport of proteins within the cell.

Its involvement in these essential processes makes it a key target for research on synaptic function, neuronal development, and neurodegenerative diseases. By studying the functions of VAMP3, researchers can gain insights into the mechanisms underlying cellular communication and disease pathogenesis, paving the way for the development of novel therapeutic strategies.

Product Name:VAMP3 Antibody
Product Sku:CPAB0535
Size:5μg
Host Species:Mouse
Immunogen:Anti-human VAMP3 mAb is derived from hybridization of mouse F myeloma cells with spleen cells from BALB/c mice immunized with recombinant human VAMP3 amino acids 1-77 purified from Ecoli.
Clone:Pk2A2AT.
Reactivity:Other bodies
Applications:Western Blot, ELISA
Purification Method:VAMP3 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
Isotype:IgG2b
Background:VAMP3 is present in recycling endosomes and endosome-derived vesicles. VAMP3 has been implicated in recycling of transferrin receptors to the plasma membrane, secretion of alpha-granules in platelets, recycling of T-cell receptors to the immunological synapses, and membrane trafficking during cell migration. VAMP-3 is present in human platelets and necessary for granule secretion. Synaptobrevins are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. VAMP3 high homology to other VAMPs in its broad tissue distribution and subcellular localization is shown to be the human equivalent of the rodent cellubrevin. In platelets the protein resides on a compartment that is not mobilized to the plasma membrane on calcium or thrombin stimulation.
Synonyms:VAMP3, VAMP-3, Cellubrevin, Vesicle-Associated Membrane Protein 3, Synaptobrevin-3, CEB, SYB3.
Storage Buffer:For periods up to 1 month store at 4°C, for longer periods of time, store at -20°C. Prevent freeze thaw cycles.

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