The VAMP2 Polyclonal Antibody (CAB4235) is a valuable tool for researchers studying VAMP2, a protein involved in membrane fusion and neurotransmitter release. This rabbit monoclonal antibody is highly specific for detecting VAMP2 in human samples and has been validated for use in Western blotting applications. By binding to the VAMP2 protein, this antibody enables accurate detection and analysis in different cell types, making it an ideal choice for studies in neuroscience and neurodegenerative diseases.VAMP2, also known as synaptobrevin 2, plays a crucial role in synaptic vesicle fusion and neurotransmitter release in neurons.
Dysregulation of VAMP2 has been implicated in various neurological disorders, including Alzheimer's disease and Parkinson's disease. By understanding the function and regulation of VAMP2, researchers can gain insights into the mechanisms underlying these conditions and potentially develop new therapeutic strategies.Overall, the VAMP2 Polyclonal Antibody (CAB4235) is a reliable tool for studying VAMP2 and its role in synaptic transmission, making it essential for researchers working in the fields of neuroscience, neurobiology, and neurodegenerative diseases.
Product Name:
VAMP2 Rabbit Monoclonal Antibody
SKU:
CAB4235
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VAMP2 (P63027).
Cell junction, Cell membrane, Cytoplasmic vesicle, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
Calculated MW:
13kDa
Observed MW:
17kDa
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Purification Method:
Affinity purification
Gene ID:
6844
Clone Number:
ARC0936
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using VAMP2 Rabbit mAb (CAB4235) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
