The VAMP2 Polyclonal Antibody (CAB1249) is a valuable tool for research involving the vesicle-associated membrane protein 2 (VAMP2), a key protein involved in synaptic vesicle exocytosis and neurotransmitter release. This antibody, developed using rabbit immunization, is highly specific to human VAMP2 and has been validated for use in Western blot applications. By binding to the VAMP2 protein, this antibody enables accurate detection and analysis of VAMP2 expression in various cell types, making it an ideal choice for studies in neuroscience and neurology research.VAMP2 plays a crucial role in synaptic transmission by mediating the fusion of neurotransmitter-containing vesicles with the plasma membrane.
Dysregulation of VAMP2 function has been implicated in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease, making it a promising target for therapeutic interventions. Understanding the mechanisms underlying VAMP2-mediated neurotransmitter release is essential for developing novel treatment strategies for these debilitating conditions. The VAMP2 Polyclonal Antibody (CAB1249) provides researchers with a reliable tool to explore the role of VAMP2 in synaptic function and neuronal communication.
Product Name:
VAMP2 Rabbit Polyclonal Antibody
SKU:
CAB1249
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human VAMP2 (NP_055047.2).
Cell junction, Cell membrane, Cytoplasmic vesicle, Single-pass type IV membrane protein, secretory vesicle, synapse, synaptic vesicle membrane, synaptosome.
Calculated MW:
13kDa
Observed MW:
16kDa
The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG.
Purification Method:
Affinity purification
Gene ID:
6844
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using VAMP2 Rabbit pAb (CAB1249) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
