VAMP2 Antibody (PACO20849)
- SKU:
- PACO20849
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- WB
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
VAMP2 Antibody (PACO20849)
The VAMP2 Polyclonal Antibody (PAC020849) is a valuable tool for researchers studying the vesicle-associated membrane protein 2 (VAMP2), a key player in the process of neurotransmitter release. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in Western blot applications. By targeting the VAMP2 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in neuroscience and neurobiology.VAMP2 is essential for the fusion of synaptic vesicles with the presynaptic membrane, allowing for the release of neurotransmitters and ultimately, communication between neurons. Dysregulation of VAMP2 function has been implicated in various neurological disorders, including epilepsy, Parkinson's disease, and Alzheimer's disease.
By understanding the role of VAMP2 in neurotransmission, researchers can gain insights into the mechanisms underlying these conditions and potentially identify new therapeutic targets.Overall, the VAMP2 Polyclonal Antibody is a valuable resource for scientists investigating the intricate processes of synaptic transmission and seeking to unravel the complexities of the nervous system. Its high specificity and reliability make it an essential tool for advancing our understanding of neurological disorders and developing targeted therapies for these conditions.
| Antibody Name: | VAMP2 Antibody (PACO20849) |
| Antibody SKU: | PACO20849 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human VAMP2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20849(VAMP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 12%SDS-PAGE,Lysate: 40 µg,Lane 1-3: Human fetal brain tissue, Mouse brain tissue, Hela cells,Primary antibody: PACO20849(VAMP2 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 30 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20849(VAMP2 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. |
| Synonyms: | vesicle-associated membrane protein 2 (synaptobrevin 2) |
| UniProt Protein Function: | VAMP2: a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. Thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. |
| UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Vesicle; Membrane protein, integral Chromosomal Location of Human Ortholog: 17p13.1 Cellular Component: zymogen granule membrane; neuron projection; synaptic vesicle membrane; intracellular membrane-bound organelle; clathrin-coated vesicle; integral to plasma membrane; secretory granule membrane; trans-Golgi network; cytosol; secretory granule; SNARE complex; synaptic vesicle; membrane; perinuclear region of cytoplasm; plasma membrane; synapse; cytoplasmic vesicle; cell junction Molecular Function:calmodulin binding; SNAP receptor activity; protein binding; SNARE binding; protein self-association; syntaxin binding; syntaxin-1 binding; phospholipid binding; calcium-dependent protein binding Biological Process: exocytosis; natural killer cell degranulation; neurotransmitter secretion; neutrophil degranulation; pathogenesis; calcium ion-dependent exocytosis; vesicle fusion; regulation of exocytosis; vesicle-mediated transport; synaptic transmission; protein transport; synaptic vesicle exocytosis; cellular protein metabolic process; glutamate secretion; cellular response to insulin stimulus; Golgi to plasma membrane protein transport; response to glucose stimulus; energy reserve metabolic process; eosinophil degranulation; protein complex assembly; post-Golgi vesicle-mediated transport; regulation of insulin secretion |
| NCBI Summary: | The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P63027 |
| NCBI GenInfo Identifier: | 288558837 |
| NCBI Gene ID: | 6844 |
| NCBI Accession: | P63027.3 |
| UniProt Secondary Accession: | P63027,P19065, Q9BUC2, |
| UniProt Related Accession: | P63027 |
| Molecular Weight: | 13kDa |
| NCBI Full Name: | Vesicle-associated membrane protein 2 |
| NCBI Synonym Full Names: | vesicle-associated membrane protein 2 (synaptobrevin 2) |
| NCBI Official Symbol: | VAMP2Â Â |
| NCBI Official Synonym Symbols: | SYB2; VAMP-2Â Â |
| NCBI Protein Information: | vesicle-associated membrane protein 2; synaptobrevin 2; synaptobrevin-2; vesicle associated membrane protein 2 |
| UniProt Protein Name: | Vesicle-associated membrane protein 2 |
| UniProt Synonym Protein Names: | Synaptobrevin-2 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP2Â Â |
| UniProt Entry Name: | VAMP2_HUMAN |
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