The VAMP1 Polyclonal Antibody (CAB8877) is a vital tool for researchers studying VAMP1, a protein involved in intracellular membrane fusion and neurotransmitter release. This antibody, produced in rabbits, demonstrates high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the VAMP1 protein, this antibody facilitates the detection and analysis of VAMP1 in various cell types, making it an essential tool for studies in neuroscience and cell biology.VAMP1, also known as synaptobrevin-1, plays a crucial role in synaptic vesicle trafficking and neurotransmitter release, making it a key player in neuronal communication.
Understanding the functions and regulation of VAMP1 is essential for unraveling the complexities of synaptic transmission and neuronal signaling. This antibody serves as a valuable tool for researchers investigating neurological disorders, such as Alzheimer's disease and Parkinson's disease, where abnormalities in synaptic function are implicated. By studying VAMP1, researchers can gain insights into the underlying mechanisms of these disorders and potentially identify new therapeutic targets.
Product Name:
VAMP1 Rabbit Polyclonal Antibody
SKU:
CAB8877
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-96 of human VAMP1 (NP_954740.1).
Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined.
Purification Method:
Affinity purification
Gene ID:
6843
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using VAMP1 Rabbit pAb (CAB8877) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
