VAMP1 Antibody (PACO20847)
- SKU:
- PACO20847
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
VAMP1 Antibody (PACO20847)
The VAMP1 Polyclonal Antibody (PAC020847) is a valuable tool for researchers studying vesicle-associated membrane protein 1 (VAMP1), a key player in membrane fusion processes within cells. This antibody, produced in rabbits, exhibits high reactivity towards human samples and has been validated for use in Western blot applications. By specifically binding to the VAMP1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in cell biology and neuroscience.VAMP1, also known as synaptobrevin 1, is essential for synaptic vesicle exocytosis and neurotransmitter release in neurons. Its role in regulating membrane fusion events highlights its importance in various cellular processes, including synaptic transmission and intracellular trafficking.
Research on VAMP1 is crucial for understanding neuronal communication and synaptic function, making this antibody a valuable resource for investigations into neurological disorders and neurodegenerative diseases.Overall, the VAMP1 Polyclonal Antibody (PAC020847) offers researchers a reliable tool for studying VAMP1 and its functions in cellular communication and membrane dynamics. Its high specificity and sensitivity make it a valuable asset for advancing research in neuroscience and cell biology.
| Antibody Name: | VAMP1 Antibody (PACO20847) |
| Antibody SKU: | PACO20847 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:20-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human VAMP1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO20847(VAMP1 Antibody) at dilution 1/25, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. |
| Synonyms: | vesicle-associated membrane protein 1 (synaptobrevin 1) |
| UniProt Protein Function: | VAMP1: Involved in the targeting and/or fusion of transport vesicles to their target membrane. Belongs to the synaptobrevin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Membrane protein, integral Chromosomal Location of Human Ortholog: 12p Cellular Component: cell junction; cell surface; cytosol; integral to plasma membrane; mitochondrial outer membrane; synaptic vesicle membrane; terminal button Molecular Function:protein binding; SNAP receptor activity; SNARE binding Biological Process: vesicle fusion Disease: Spastic Ataxia 1, Autosomal Dominant |
| NCBI Summary: | Synapotobrevins, syntaxins, and the synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Mutations in this gene are associated with autosomal dominant spastic ataxia 1. Multiple alternative splice variants have been described, but the full-length nature of some variants has not been defined. [provided by RefSeq, Jul 2014] |
| UniProt Code: | P23763 |
| NCBI GenInfo Identifier: | 135093 |
| NCBI Gene ID: | 6843 |
| NCBI Accession: | P23763.1 |
| UniProt Secondary Accession: | P23763,O75468, Q15857, Q6FG94, Q8IVC9, A8MVP3, D3DUR3 |
| UniProt Related Accession: | P23763 |
| Molecular Weight: | 12,658 Da |
| NCBI Full Name: | Vesicle-associated membrane protein 1 |
| NCBI Synonym Full Names: | vesicle associated membrane protein 1 |
| NCBI Official Symbol: | VAMP1Â Â |
| NCBI Official Synonym Symbols: | SYB1; SPAX1; VAMP-1Â Â |
| NCBI Protein Information: | vesicle-associated membrane protein 1 |
| UniProt Protein Name: | Vesicle-associated membrane protein 1 |
| UniProt Synonym Protein Names: | Synaptobrevin-1 |
| Protein Family: | Vesicle-associated membrane protein |
| UniProt Gene Name: | VAMP1Â Â |
| UniProt Entry Name: | VAMP1_HUMAN |
| Antibodies |
| Anti-VAMP1 Antibody (CAB8877) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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