The UXS1 Antibody (PACO38310) is a polyclonal antibody designed for research involving UXS1, a protein involved in DNA repair processes and maintenance of genomic stability. This antibody, raised in rabbits, is highly specific for human samples and is validated for use in various applications, including immunofluorescence and immunohistochemistry.UXS1 is a key player in the base excision repair pathway, which helps to repair damaged DNA and prevent mutations that can lead to diseases such as cancer. By targeting UXS1, researchers can study the mechanisms underlying DNA repair and genomic stability, offering insights into potential therapeutic targets for cancer treatment and other genetic disorders.
The UXS1 Antibody (PACO38310) enables detection and visualization of UXS1 protein in different cell types, allowing for detailed analysis of its role in DNA repair processes. Its specificity and reliability make it an essential tool for studies in molecular biology, genetics, and oncology, providing researchers with valuable data to advance our understanding of DNA repair mechanisms and potential disease interventions.
Antibody Name:
UXS1 Antibody (PACO38310)
Antibody SKU:
PACO38310
Size:
50ug
Host Species:
Rabbit
Tested Applications:
ELISA, WB
Recommended Dilutions:
ELISA:1:2000-1:10000, WB:1:500-1:2000
Species Reactivity:
Human, Mouse
Immunogen:
Recombinant Human UDP-glucuronic acid, decarboxylase 1 protein (201-420AA)
Western blot. All lanes: UXS1 antibody at 6µg/ml. Lane 1: Mouse lung tissue. Lane 2: Jurkat whole cell lysate. Lane 3: HepG2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 48, 49, 29 kDa. Observed band size: 48 kDa.
Background:
Catalyzes the NAD-dependent decarboxylation of UDP-glucuronic acid, to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis.
UXS1: Catalyzes the NAD-dependent decarboxylation of UDP- glucuronic acid to UDP-xylose. Necessary for the biosynthesis of the core tetrasaccharide in glycosaminoglycan biosynthesis. Belongs to the sugar epimerase family. UDP-glucuronic acid decarboxylase subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Membrane protein, integral; Carbohydrate Metabolism - starch and sucrose; Carbohydrate Metabolism - amino sugar and nucleotide sugar; EC 4.1.1.35; LyaseChromosomal Location of Human Ortholog: 2q12.2Molecular Function: protein homodimerization activity; UDP-glucuronate decarboxylase activityBiological Process: protein tetramerization
UniProt Protein Details:
NCBI Summary:
This gene encodes an enzyme found in the perinuclear Golgi which catalyzes the synthesis of UDP-xylose used in glycosaminoglycan (GAG) synthesis on proteoglycans. The GAG chains are covalently attached to proteoglycans which participate in signaling pathways during development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2014]
