The UVRAG Polyclonal Antibody (CAB8462) is a valuable tool for researchers studying the UVRAG protein, a key player in the autophagy pathway. This antibody, produced in rabbits, is highly specific for human samples and has been validated for use in Western blot applications. By binding to the UVRAG protein, researchers can easily detect and analyze its expression in various cell types, making it an essential reagent for studies in cell biology and cancer research.UVRAG, also known as UV radiation resistance-associated gene protein, is essential for autophagy regulation and plays a crucial role in maintaining cellular homeostasis.
Dysregulation of the autophagy pathway has been linked to various diseases, including cancer and neurodegenerative disorders, making UVRAG a promising target for therapeutic intervention. By understanding the functions of UVRAG, researchers can develop novel strategies to modulate autophagy and potentially treat these debilitating conditions.
Product Name:
UVRAG Rabbit Polyclonal Antibody
SKU:
CAB8462
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 501-699 of human UVRAG (NP_003360.2).
Chromosome, Early endosome, Endoplasmic reticulum, Late endosome, Lysosome, Midbody, centromere.
Calculated MW:
78kDa
Observed MW:
100kDa
This gene complements the ultraviolet sensitivity of xeroderma pigmentosum group C cells and encodes a protein with a C2 domain. The protein activates the Beclin1-PI(3)KC3 complex, promoting autophagy and suppressing the proliferation and tumorigenicity of human colon cancer cells. Chromosomal aberrations involving this gene are associated with left-right axis malformation and mutations in this gene have been associated with colon cancer.
Purification Method:
Affinity purification
Gene ID:
7405
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using UVRAG Rabbit pAb (CAB8462) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
