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USP9X Antibody (PACO20840)

SKU:
PACO20840
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
$407
Frequently bought together:

Description

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USP9X Antibody (PACO20840)

The USP9X Monoclonal Antibody (PAC020840) is a powerful tool for research involving USP9X, a deubiquitinase enzyme involved in various cellular processes, including protein degradation and DNA repair. This antibody, generated in mice, exhibits high specificity and sensitivity towards USP9X in human samples, making it a reliable tool for experiments in Western blot, immunofluorescence, and immunoprecipitation.USP9X has been implicated in cancer progression, neurodegenerative disorders, and developmental abnormalities, highlighting its importance as a potential therapeutic target.

By using the USP9X Monoclonal Antibody, researchers can explore the role of USP9X in these disease contexts and discover new insights into its molecular functions. This antibody is a key asset for studies in oncology, neuroscience, and developmental biology, providing valuable data for the development of targeted therapies and interventions.

Antibody Name:USP9X Antibody (PACO20840)
Antibody SKU:PACO20840
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, IHC
Recommended Dilutions:ELISA:1:2000-1:10000, IHC:1:30-1:150
Species Reactivity:Human, Mouse
Immunogen:Synthetic peptide of human USP9X
Form:Liquid
Storage Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Purification Method:Antigen affinity purification
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Product ImageThe image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20840(USP9X Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200).
Background:This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Synonyms:ubiquitin specific peptidase 9, X-linked
UniProt Protein Function:USP9X: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin. Widely expressed in embryonic and adult tissues. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:EC 3.4.19.12; Protease; Ubiquitin-specific protease; Ubiquitin conjugating system

Chromosomal Location of Human Ortholog: Xp11.4

Cellular Component: growth cone; membrane; apical part of cell; cytoplasm; cytosol

Molecular Function:protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; cysteine-type peptidase activity

Biological Process: mitosis; proteasomal ubiquitin-dependent protein catabolic process; transcription initiation from RNA polymerase II promoter; protein deubiquitination; transcription, DNA-dependent; axon extension; in utero embryonic development; hippocampus development; neuron migration; female gamete generation; negative regulation of transcription from RNA polymerase II promoter; cerebellar cortex structural organization; post-embryonic development; chromosome segregation; BMP signaling pathway; cell division; transforming growth factor beta receptor signaling pathway; gene expression

Disease: Mental Retardation, X-linked 99

NCBI Summary:This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
UniProt Code:Q93008
NCBI GenInfo Identifier:317373496
NCBI Gene ID:8239
NCBI Accession:Q93008.3
UniProt Secondary Accession:Q93008,O75550, Q8WWT3, Q8WX12,
UniProt Related Accession:Q93008
Molecular Weight:2570
NCBI Full Name:Probable ubiquitin carboxyl-terminal hydrolase FAF-X
NCBI Synonym Full Names:ubiquitin specific peptidase 9, X-linked
NCBI Official Symbol:USP9X  
NCBI Official Synonym Symbols:FAF; FAM; DFFRX; MRX99  
NCBI Protein Information:probable ubiquitin carboxyl-terminal hydrolase FAF-X; hFAM; fat facets in mammals; ubiquitin thioesterase FAF-X; deubiquitinating enzyme FAF-X; ubiquitin thiolesterase FAF-X; fat facets protein related, X-linked; fat facets protein-related, X-linked; Dros
UniProt Protein Name:Probable ubiquitin carboxyl-terminal hydrolase FAF-X
UniProt Synonym Protein Names:Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X
Protein Family:Probable ubiquitin carboxyl-terminal hydrolase
UniProt Gene Name:USP9X  
UniProt Entry Name:USP9X_HUMAN
Antibodies
Anti-USP9X Antibody (CAB16307)
Secondary Antibody
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)
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