USP9X Antibody (PACO20839)
- SKU:
- PACO20839
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
USP9X Antibody (PACO20839)
The USP9X Polyclonal Antibody (PAC020839) is a valuable tool for researchers studying USP9X, a deubiquitinating enzyme involved in various cellular processes, including cell cycle progression and DNA damage repair. This antibody, produced in rabbits, exhibits high specificity and sensitivity towards human samples, making it a reliable choice for Western blot applications.USP9X, also known as ubiquitin-specific protease 9, plays a crucial role in maintaining cellular homeostasis by regulating protein stability and turnover. Dysregulation of USP9X has been implicated in cancer development and progression, making it a promising target for therapeutic interventions.
The USP9X Polyclonal Antibody enables researchers to study the expression and function of USP9X in different cell types, providing insights into its role in cancer biology and potential drug targets.This antibody is an essential tool for investigating the molecular mechanisms underlying USP9X-mediated processes, offering valuable insights into its physiological functions and disease relevance. Its high reactivity and specificity make it an ideal choice for researchers exploring the therapeutic potential of targeting USP9X in cancer and other related disorders.
| Antibody Name: | USP9X Antibody (PACO20839) |
| Antibody SKU: | PACO20839 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human USP9X |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20839(USP9X Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20839(USP9X Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. |
| Synonyms: | ubiquitin specific peptidase 9, X-linked |
| UniProt Protein Function: | USP9X: Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important role regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Interacts with SMAD4, MARK4, NUAK1 and BIRC5/survivin. Widely expressed in embryonic and adult tissues. Belongs to the peptidase C19 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Protease; Ubiquitin-specific protease; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: Xp11.4 Cellular Component: growth cone; membrane; apical part of cell; cytoplasm; cytosol Molecular Function:protein binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity; cysteine-type peptidase activity Biological Process: mitosis; proteasomal ubiquitin-dependent protein catabolic process; transcription initiation from RNA polymerase II promoter; protein deubiquitination; transcription, DNA-dependent; axon extension; in utero embryonic development; hippocampus development; neuron migration; female gamete generation; negative regulation of transcription from RNA polymerase II promoter; cerebellar cortex structural organization; post-embryonic development; chromosome segregation; BMP signaling pathway; cell division; transforming growth factor beta receptor signaling pathway; gene expression Disease: Mental Retardation, X-linked 99 |
| NCBI Summary: | This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q93008 |
| NCBI GenInfo Identifier: | 317373496 |
| NCBI Gene ID: | 8239 |
| NCBI Accession: | Q93008.3 |
| UniProt Secondary Accession: | Q93008,O75550, Q8WWT3, Q8WX12, |
| UniProt Related Accession: | Q93008 |
| Molecular Weight: | 2570 |
| NCBI Full Name: | Probable ubiquitin carboxyl-terminal hydrolase FAF-X |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 9, X-linked |
| NCBI Official Symbol: | USP9XÂ Â |
| NCBI Official Synonym Symbols: | FAF; FAM; DFFRX; MRX99Â Â |
| NCBI Protein Information: | probable ubiquitin carboxyl-terminal hydrolase FAF-X; hFAM; fat facets in mammals; ubiquitin thioesterase FAF-X; deubiquitinating enzyme FAF-X; ubiquitin thiolesterase FAF-X; fat facets protein related, X-linked; fat facets protein-related, X-linked; Dros |
| UniProt Protein Name: | Probable ubiquitin carboxyl-terminal hydrolase FAF-X |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme FAF-X; Fat facets in mammals; hFAM; Fat facets protein-related, X-linked; Ubiquitin thioesterase FAF-X; Ubiquitin-specific protease 9, X chromosome; Ubiquitin-specific-processing protease FAF-X |
| Protein Family: | Probable ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP9XÂ Â |
| UniProt Entry Name: | USP9X_HUMAN |
| Antibodies |
| Anti-USP9X Antibody (CAB16307) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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