The USP8 Polyclonal Antibody (CAB7031) is a valuable tool for researchers studying USP8, a ubiquitin-specific protease implicated in various cellular processes, including protein degradation and cell signaling. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications.USP8, also known as ubiquitin-specific processing protease 8, is involved in the regulation of key signaling pathways, such as the epidermal growth factor receptor (EGFR) pathway. Dysregulation of USP8 has been linked to various diseases, including cancer and neurodegenerative disorders.
As such, understanding the function of USP8 is crucial for developing targeted therapies and treatments.By targeting the USP8 protein, researchers can gain insight into its role in cellular processes and its potential as a therapeutic target. The USP8 Polyclonal Antibody enables the detection and analysis of USP8 in different cell types, making it an essential tool for studies in cell biology, signaling pathways, and disease mechanisms.
Product Name:
USP8 Rabbit Polyclonal Antibody
SKU:
CAB7031
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human USP8 (NP_005145.3).
This gene encodes a protein that belongs to the ubiquitin-specific processing protease family of proteins. The encoded protein is thought to regulate the morphology of the endosome by ubiquitination of proteins on this organelle and is involved in cargo sorting and membrane trafficking at the early endosome stage. This protein is required for the cell to enter the S phase of the cell cycle and also functions as a positive regulator in the Hedgehog signaling pathway in development. Pseudogenes of this gene are present on chromosomes 2 and 6. Alternate splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
9101
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using (CAB7031) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
