The USP7 Polyclonal Antibody (CAB2345) is a valuable tool for research involving USP7, a deubiquitinating enzyme with important roles in cellular processes such as DNA repair, apoptosis, and gene expression regulation. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the USP7 protein, researchers can detect and analyze its expression in various cell types, making it ideal for studies in molecular biology and cancer research.
USP7, also known as ubiquitin-specific protease 7, is a key player in the intricate network of protein degradation pathways. Its involvement in regulating the stability and activity of various proteins positions it as a potential target for therapeutic intervention in diseases like cancer, neurodegenerative disorders, and viral infections. Studying the function of USP7 is essential for unraveling its role in disease development and progression, paving the way for the development of novel treatment strategies.
Product Name:
USP7/HAUSP Rabbit Polyclonal Antibody
SKU:
CAB2345
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 206-1102 of human USP7/HAUSP (NP_003461.2).
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder.
Purification Method:
Affinity purification
Gene ID:
7874
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using USP7/HAUSP Rabbit pAb (CAB2345) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.
