The USP7 Polyclonal Antibody (CAB13564) is a valuable tool for researchers studying USP7, a deubiquitinating enzyme with important roles in cellular processes such as DNA repair, apoptosis, and transcriptional regulation. This antibody, derived from rabbits, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to the USP7 protein, this antibody enables the detection and analysis of USP7 in various cell types, making it ideal for investigations in molecular biology, cancer research, and drug development.USP7, also known as HAUSP (herpesvirus-associated ubiquitin-specific protease), is a key regulator of protein stability and function through its interaction with numerous target proteins, including tumor suppressors and oncogenes.
Dysregulation of USP7 has been implicated in various diseases, including cancer, neurological disorders, and viral infections. Understanding the functions and mechanisms of USP7 is essential for the development of targeted therapies that exploit its role in disease pathogenesis.Overall, the USP7 Polyclonal Antibody (CAB13564) offers researchers a reliable tool for investigating the complex roles of USP7 in cellular biology and disease mechanisms, paving the way for new insights and potential therapeutic strategies.
Product Name:
USP7/HAUSP Rabbit Polyclonal Antibody
SKU:
CAB13564
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 206-1102 of human USP7/HAUSP (NP_003461.2).
The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder.
Purification Method:
Affinity purification
Gene ID:
7874
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of various lysates using USP7/HAUSP Rabbit pAb (CAB13564) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
