USP5 Rabbit Polyclonal Antibody (CAB4202)
- SKU:
- CAB4202
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | USP5 Rabbit Polyclonal Antibody |
SKU: | CAB4202 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP5 (NP_003472.2). |
Sequence: | MAEL SEEA LLSV LPTI RVPK AGDR VHKD ECAF SFDT PESE GGLY ICMN TFLG FGKQ YVER HFNK TGQR VYLH LRRT RRPK EEDP ATGT GDPP RKKP TRLA IGVE GGFD LSEE KFEL DEDV KIVI LPDY LEIA RDGL GGLP DIVR DRVT SAVE ALLS ADSA SRKQ EVQA WDGE VRQV SKHA FSLK QLDN PARI PPCG WKCS KCDM RENL WLNL TDGS ILCG RRYF DGSG GNNH AVEH YRET GYPL AVKL GTIT PDGA DVYS YDED DMVL DPSL AEHL SHFG |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:2000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ISOT; USP5 |
Positive Sample: | LO2,A-549,293T,HeLa,Jurkat,22Rv1,Mouse kidney,Mouse brain |
Conjugate: | Unconjugated |
Cellular Localization: | cytosol, lysosome, nucleus |
Calculated MW: | 96kDa |
Observed MW: | 110kDa |
Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).
Purification Method: | Affinity purification |
Gene ID: | 8078 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3. |