The USP48 Polyclonal Antibody (CAB5046) is a vital tool for researchers studying USP48, a deubiquitinating enzyme that plays a key role in cellular processes such as protein degradation and signaling pathways. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been specifically validated for use in Western blot applications. By binding to the USP48 protein, this antibody allows for accurate detection and analysis in a variety of cell types, making it an essential asset for studies in molecular biology and cancer research.
USP48, also known as ubiquitin-specific protease 48, is involved in regulating protein turnover and maintaining cellular homeostasis. Its functions in the ubiquitin-proteasome system make it a target of interest in understanding diseases such as cancer, neurodegenerative disorders, and immune-related conditions. By studying the activity of USP48, researchers can gain insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
USP48 Rabbit Polyclonal Antibody
SKU:
CAB5046
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human USP48 (NP_115612.4).
This gene encodes a protein containing domains that associate it with the peptidase family C19, also known as family 2 of ubiquitin carboxyl-terminal hydrolases. Family members function as deubiquitinating enzymes, recognizing and hydrolyzing the peptide bond at the C-terminal glycine of ubiquitin. Enzymes in peptidase family C19 are involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
Purification Method:
Affinity purification
Gene ID:
84196
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using USP48 Rabbit pAb (CAB5046) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
