The USP47 Polyclonal Antibody (CAB15461) is a valuable tool for researchers studying USP47, a deubiquitinase enzyme that plays a key role in the regulation of protein turnover and stability. This antibody, raised in rabbits, exhibits high specificity and sensitivity for USP47 in human samples, making it suitable for Western blot applications. By binding to USP47, researchers can accurately detect and analyze the enzyme's expression levels in various cell types, facilitating investigations in areas such as cell signaling pathways, protein degradation, and cancer biology.USP47 is critical for maintaining cellular homeostasis by controlling the degradation of proteins involved in key cellular processes, including DNA repair, cell cycle progression, and apoptosis.
Dysregulation of USP47 has been linked to various diseases, making it a promising therapeutic target for conditions such as cancer, neurodegenerative disorders, and inflammatory diseases. Studying the role of USP47 with the help of this antibody can provide insights into disease mechanisms and aid in the development of targeted treatments aimed at restoring protein balance and cellular function.
Product Name:
USP47 Rabbit Polyclonal Antibody
SKU:
CAB15461
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1128-1287 of human USP47 (NP_060414.3).
Enables WD40-repeat domain binding activity and thiol-dependent deubiquitinase. Involved in several processes, including monoubiquitinated protein deubiquitination; negative regulation of G2/M transition of mitotic cell cycle; and negative regulation of nitrogen compound metabolic process. Located in cytoplasm. Part of SCF ubiquitin ligase complex.
Purification Method:
Affinity purification
Gene ID:
55031
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using USP47 Rabbit pAb (CAB15461) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
