The USP46 Polyclonal Antibody (CAB17863) is specifically designed for researchers investigating USP46, a key enzyme involved in protein degradation and regulation. This antibody, derived from rabbit serum, exhibits high reactivity with human samples and has been validated for use in Western blotting applications. By binding to the USP46 protein, this antibody enables the visualization and analysis of USP46 expression in a variety of cell types, making it an essential tool for studies in molecular biology and drug discovery.USP46 is a deubiquitinating enzyme that plays a crucial role in maintaining protein stability and turnover within cells.
Dysregulation of USP46 has been implicated in various diseases, including cancer, neurodegenerative disorders, and metabolic syndromes. By understanding the function and regulation of USP46, researchers can potentially develop targeted therapies aimed at modulating protein degradation processes in disease states. The USP46 Polyclonal Antibody offers a valuable resource for investigating the role of USP46 in cellular homeostasis and disease pathology.
Product Name:
USP46 Rabbit Polyclonal Antibody
SKU:
CAB17863
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human USP46 (NP_073743.2).
Modification of cellular proteins by ubiquitin is an essential regulatory mechanism controlled by the coordinated action of multiple ubiquitin-conjugating and deubiquitinating enzymes. USP46 belongs to a large family of cysteine proteases that function as deubiquitinating enzymes (Quesada et al., 2004 [PubMed 14715245]).
Purification Method:
Affinity purification
Gene ID:
64854
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of lysates from mouse pancreas, using USP46 Rabbit pAb (CAB17863) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
