USP28 Antibody (PACO20842)
- SKU:
- PACO20842
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Applications:
- ELISA
- IHC
- Antibody Type:
- Polyclonal Antibody
- Conjugation:
- Unconjugated
Description
USP28 Antibody (PACO20842)
The USP28 Polyclonal Antibody (PAC020842) is a valuable tool for researchers studying USP28, a key regulator of protein stability and cellular processes. This antibody, generated in rabbits, exhibits high specificity and sensitivity for detecting USP28 in human samples, making it ideal for use in Western blotting and immunohistochemistry applications.USP28, a deubiquitinating enzyme, plays a vital role in protein turnover and stability by removing ubiquitin chains from target proteins, thus regulating their degradation and function.
Dysregulation of USP28 has been linked to various diseases, including cancer and neurodegenerative disorders, making it a promising therapeutic target.By using the USP28 Polyclonal Antibody, researchers can further elucidate the function and regulation of USP28 in cellular processes and disease pathways, paving the way for the development of targeted therapies and drug discovery efforts.
| Antibody Name: | USP28 Antibody (PACO20842) |
| Antibody SKU: | PACO20842 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human USP28 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO20842(USP28 Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | The ubiquitin-dependent protein degradation pathway is essential for proteolysis of intracellular proteins and peptides. Enzymes that remove ubiquitin from ubiquitin-conjugated peptides, like USP28, affect the fate and degradation of intracellular proteins and are essential for maintenance of cell-free ubiquitin pools (Valero et al., 2001). |
| Synonyms: | ubiquitin specific peptidase 28 |
| UniProt Protein Function: | USP28: a peptidase of the C19 family. USP28 and FBXW7 regulate Myc protein stability in response to DNA damage. Two isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.19.12; Protease; Ubiquitin-specific protease Chromosomal Location of Human Ortholog: 11q23.2 Cellular Component: nuclear body; nucleoplasm; protein complex Molecular Function:protein binding; ubiquitin-specific protease activity Biological Process: cell proliferation; DNA damage checkpoint; DNA damage response, signal transduction by p53 class mediator resulting in induction of apoptosis; protein deubiquitination; Ras protein signal transduction; regulation of protein stability; response to DNA damage stimulus; response to ionizing radiation |
| NCBI Summary: | The protein encoded by this gene is a deubiquitinase involved in the DNA damage pathway and DNA damage-induced apoptosis. Overexpression of this gene is seen in several cancers. [provided by RefSeq, Oct 2016] |
| UniProt Code: | Q96RU2 |
| NCBI GenInfo Identifier: | 20140700 |
| NCBI Gene ID: | 57646 |
| NCBI Accession: | Q96RU2.1 |
| UniProt Secondary Accession: | Q96RU2,Q6NZX9, Q9P213, B0YJC0, B0YJC1, |
| UniProt Related Accession: | Q96RU2 |
| Molecular Weight: | 122kDa |
| NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 28 |
| NCBI Synonym Full Names: | ubiquitin specific peptidase 28 |
| NCBI Official Symbol: | USP28Â Â |
| NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 28 |
| UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 28 |
| UniProt Synonym Protein Names: | Deubiquitinating enzyme 28; Ubiquitin thioesterase 28; Ubiquitin-specific-processing protease 28 |
| Protein Family: | Ubiquitin carboxyl-terminal hydrolase |
| UniProt Gene Name: | USP28Â Â |
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