The USP21 Polyclonal Antibody (CAB16663) is a valuable tool for researchers studying USP21, a deubiquitinating enzyme involved in various cellular processes such as DNA repair, transcriptional regulation, and cell cycle progression. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the USP21 protein, researchers can accurately detect and analyze its expression in a variety of cell types, making it an ideal choice for studies in molecular biology and cancer research.USP21, also known as ubiquitin-specific protease 21, plays a crucial role in maintaining cellular homeostasis by controlling protein stability and turnover.
Dysregulation of USP21 has been implicated in various disease states, including cancer, neurodegenerative disorders, and inflammatory conditions. Investigating the functions of USP21 is essential for uncovering its potential as a therapeutic target for these diseases and developing novel treatment strategies.Overall, the USP21 Polyclonal Antibody (CAB16663) offers researchers a reliable tool for exploring the biological functions of USP21 and its implications in disease pathology, paving the way for advancements in precision medicine and targeted therapies.
Product Name:
USP21 Rabbit Polyclonal Antibody
SKU:
CAB16663
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP21 (NP_036607.3).
Sequence:
MPQA SEHR LGRT REPP VN
Tested Applications:
WBIF/ICCELISA
Recommended Dilution:
WB,1:500 - 1:1000 IF/ICC,1:50 - 1:200
Synonyms:
USP16; USP23; USP21
Positive Sample:
Mouse brain
Conjugate:
Unconjugated
Cellular Localization:
Cytoplasm, Nucleus.
Calculated MW:
63kDa
Observed MW:
63kDa
This gene encodes a member of the C19 peptidase family, also known as family 2 of ubiquitin carboxy-terminal hydrolases. The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like protein, from NEDD8-conjugated proteins. This gene has been referred to as USP16 and USP23 but is now known as USP21. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
27005
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using USP21 antibody (CAB16663) at 1:700 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
