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USP2 Antibody (PACO13122)

SKU:
PACO13122
Product Type:
Antibody
Reactivity:
Human
Mouse
Host Species:
Rabbit
Isotype:
IgG
Applications:
ELISA
WB
IHC
Antibody Type:
Polyclonal Antibody
Conjugation:
Unconjugated
€459
Frequently bought together:

Description

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USP2 Antibody (PACO13122)

The USP2 Polyclonal Antibody (PAC013122) is an essential tool for researchers studying USP2, a protein involved in the regulation of various cellular processes. This antibody, raised in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to USP2, researchers can accurately detect and analyze this protein in a variety of cell types, making it a valuable asset for studies in cell biology and cancer research.USP2, a deubiquitinating enzyme, plays a crucial role in regulating protein stability and turnover within cells.

Its involvement in processes such as protein degradation and DNA repair highlights its importance in maintaining cellular homeostasis. Research into USP2 function is vital for understanding its impact on diseases like cancer, neurodegenerative disorders, and metabolic syndromes, offering potential therapeutic targets for drug development.By utilizing the USP2 Polyclonal Antibody, researchers can delve deeper into the mechanisms of USP2 activity and its role in disease pathogenesis, ultimately driving advancements in biomedical research and the development of novel treatments.

Antibody Name:USP2 Antibody (PACO13122)
Antibody SKU:PACO13122
Size:50ul
Host Species:Rabbit
Tested Applications:ELISA, WB, IHC
Recommended Dilutions:
Species Reactivity:Human, Mouse
Immunogen:Human USP2
Form:Liquid
Storage Buffer:PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Purification Method:Antigen Affinity Purified
Clonality:Polyclonal
Isotype:IgG
Conjugate:Non-conjugated
Synonyms:ubiquitin specific peptidase 2;USP2;UBP41;USP9 ;
UniProt Protein Function:USP2: Hydrolase that deubiquitinates polyubiquitinated target proteins such as MDM2, MDM4 and CCND1. Isoform 1 and isoform 4 possess both ubiquitin-specific peptidase and isopeptidase activities. Deubiquitinates MDM2 without reversing MDM2-mediated p53/TP53 ubiquitination and thus indirectly promotes p53/TP53 degradation and limits p53 activity. Has no deubiquitinase activity against p53/TP53. Prevents MDM2-mediated degradation of MDM4. Plays a role in the G1/S cell-cycle progression in normal and cancer cells. Plays a role in the regulation of myogenic differentiation of embryonic muscle cells. Homooligomer. Found in trimeric complex with MDM2 and MDM4 and UPB2. Interacts with CCND1; the interaction is direct and promotes its stabilization by antagonizing ubiquitin-dependent degradation. Interacts (via N-terminus and C- terminus) with MDM2. Interacts with MDM4. Down-regulated by cisplatin. Expressed in mesangial cells of the kidney and in different types of glomerulonephritides. Cleavage is inhibited by ubiquitin in a dosage- dependent manner. Cleavage is blocked by ubiquitin aldehyde. Belongs to the peptidase C19 family. USP2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.
UniProt Protein Details:

Protein type:Ubiquitin-specific protease; Protease; EC 3.4.19.12

Chromosomal Location of Human Ortholog: 11q23.3

Cellular Component: centrosome; perinuclear region of cytoplasm; cytoplasm; cell cortex; nucleus

Molecular Function:identical protein binding; protein binding; cyclin binding; ubiquitin protein ligase binding; metal ion binding; cysteine-type endopeptidase activity; ubiquitin-specific protease activity

Biological Process: proteasomal ubiquitin-dependent protein catabolic process; negative regulation of skeletal muscle development; muscle development; protein deubiquitination; protein stabilization; positive regulation of skeletal muscle development; negative regulation of transcription from RNA polymerase II promoter; positive regulation of mitotic cell cycle; cell cycle; circadian behavior; entrainment of circadian clock by photoperiod; locomotor rhythm; circadian regulation of gene expression

NCBI Summary:This gene encodes a member of the family of de-ubiquitinating enzymes, which belongs to the peptidase C19 superfamily. The encoded protein is a ubiquitin-specific protease which is required for TNF-alpha (tumor necrosis factor alpha) -induced NF-kB (nuclear factor kB) signaling. This protein deubiquitinates polyubiquitinated target proteins such as fatty acid synthase, murine double minute 2 (MDM2), MDM4/MDMX and cyclin D1. MDM2 and MDM4 are negative regulators of the p53 tumor suppressor and cyclin D1 is required for cell cycle G1/S transition. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
UniProt Code:O75604
NCBI GenInfo Identifier:20141855
NCBI Gene ID:9099
NCBI Accession:O75604.2
UniProt Secondary Accession:O75604,Q8IUM2, Q8IW04, Q96MB9, Q9BQ21, B0YJB8, E9PPM2
UniProt Related Accession:O75604
Molecular Weight:605
NCBI Full Name:Ubiquitin carboxyl-terminal hydrolase 2
NCBI Synonym Full Names:ubiquitin specific peptidase 2
NCBI Official Symbol:USP2  
NCBI Official Synonym Symbols:USP9; UBP41  
NCBI Protein Information:ubiquitin carboxyl-terminal hydrolase 2; ubiquitin thioesterase 2; deubiquitinating enzyme 2; ubiquitin specific protease 9; ubiquitin specific protease 12; 41 kDa ubiquitin-specific protease; ubiquitin-specific-processing protease 2
UniProt Protein Name:Ubiquitin carboxyl-terminal hydrolase 2
UniProt Synonym Protein Names:41 kDa ubiquitin-specific protease; Deubiquitinating enzyme 2; Ubiquitin thioesterase 2; Ubiquitin-specific-processing protease 2
Protein Family:Protein
UniProt Gene Name:USP2  
UniProt Entry Name:UBP2_HUMAN

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