The USP18 Polyclonal Antibody (CAB16739) is a vital tool for researchers studying USP18, a key regulator of interferon signaling and immune response. This antibody, produced in rabbits, exhibits high specificity and sensitivity in detecting USP18 in human samples, making it a reliable choice for Western blot applications. By binding to the USP18 protein, this antibody enables precise detection and analysis in various cell types, facilitating investigations in immunology and infectious disease research.USP18, also known as UBP43, is a crucial modulator of interferon-stimulated genes and plays a pivotal role in regulating antiviral responses and immune activation.
Its involvement in interferon signaling pathways makes it a promising target for exploring novel treatment strategies against viral infections, autoimmune diseases, and inflammatory disorders. The USP18 Polyclonal Antibody is an indispensable tool for deciphering the intricate mechanisms of USP18 function and its implications in various disease settings.
Product Name:
USP18 Rabbit Polyclonal Antibody
SKU:
CAB16739
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP18 (NP_059110.2).
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.
Purification Method:
Affinity purification
Gene ID:
11274
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates using USP18 Rabbit pAb (CAB16739) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 60s.
