USP18 Rabbit Polyclonal Antibody (CAB16739)
- SKU:
- CAB16739
- Product Type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Signal Transduction
Frequently bought together:
Description
Product Name: | USP18 Rabbit Polyclonal Antibody |
SKU: | CAB16739 |
Size: | 20uL, 100uL |
Isotype: | IgG |
Host Species: | Rabbit |
Reactivity: | Human,Mouse,Rat |
Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human USP18 (NP_059110.2). |
Sequence: | MSKA FGLL RQIC QSIL AESS QSPA DLEE KKEE DSNM KREQ PRER PRAW DYPH GLVG LHNI GQTC CLNS LIQV FVMN VDFT RILK RITV PRGA DEQR RSVP |
Tested Applications: | WB IHC-P IF/ICC ELISA |
Recommended Dilution: | WB,1:1000 - 1:5000 IHC-P,1:50 - 1:200 IF/ICC,1:50 - 1:200 |
Synonyms: | ISG43; UBP43; PTORCH2; USP18 |
Positive Sample: | Hep G2,Mouse liver |
Cellular Localization: | cytosol, nucleus |
Calculated MW: | 43kDa |
Observed MW: | 34kDa |
The protein encoded by this gene belongs to the ubiquitin-specific proteases (UBP) family of enzymes that cleave ubiquitin from ubiquitinated protein substrates. It is highly expressed in liver and thymus, and is localized to the nucleus. This protein efficiently cleaves only ISG15 (a ubiquitin-like protein) fusions, and deletion of this gene in mice results in a massive increase of ISG15 conjugates in tissues, indicating that this protein is a major ISG15-specific protease. Mice lacking this gene are also hypersensitive to interferon, suggesting a function of this protein in downregulating interferon responses, independent of its isopeptidase activity towards ISG15.
Purification Method: | Affinity purification |
Gene ID: | 11274 |
Storage Buffer: | Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3. |