The USP17L5 Antibody (PAC062435) is a high-quality polyclonal antibody developed for research purposes involving USP17L5, a member of the ubiquitin-specific protease (USP) family that is involved in regulating various cellular processes. This antibody, produced in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications.USP17L5 is known to play a crucial role in the ubiquitin-proteasome system, which is essential for protein degradation and turnover in cells. Dysfunction in this system has been implicated in various diseases, including cancer and neurodegenerative disorders. By targeting USP17L5, researchers can gain valuable insights into the mechanisms underlying these diseases and potentially identify new therapeutic targets.
The USP17L5 Antibody provides researchers with a powerful tool for studying the function and regulation of USP17L5 in different cell types and experimental settings. Its specificity and sensitivity make it an ideal choice for studies in the fields of cell biology, molecular biology, and drug discovery. By understanding the role of USP17L5, scientists can further advance our knowledge of cellular processes and potentially uncover novel strategies for treating and preventing disease.
IHC image of PACO62435 diluted at 1:400 and staining in paraffin-embedded human liver cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Western Blot. Positive WB detected in: Hela whole cell lysate. All lanes: USP17L5 antibody at 1:2000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 60 kDa. Observed band size: 60 kDa.
IHC image of PACO62435 diluted at 1:400 and staining in paraffin-embedded human gastric cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
Background:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
Synonyms:
Ubiquitin carboxyl-terminal hydrolase 17-like protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme 17-like protein 5) (Ubiquitin thioesterase 17-like protein 5) (Ubiquitin-specific-processing protease 17-like protein 5), USP17L5
UniProt Protein Function:
Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes that may include cell proliferation, progression through the cell cycle, apoptosis, cell migration, and the cellular response to viral infection.
