The USP15 Polyclonal Antibody (CAB6786) is a valuable tool for researchers studying USP15, a deubiquitinating enzyme involved in regulating cellular processes such as DNA repair and protein stability. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to USP15, researchers can detect and analyze this enzyme in a variety of cell types, making it an ideal choice for studies in cell biology and cancer research.
USP15 plays a critical role in the regulation of key cellular pathways, including the DNA damage response and the clearance of misfolded proteins. Dysregulation of USP15 has been implicated in diseases such as cancer, neurodegenerative disorders, and inflammatory conditions. By studying the function of USP15, researchers can gain valuable insights into the molecular mechanisms underlying these diseases and potentially identify new therapeutic targets for intervention.
Product Name:
USP15 Rabbit Polyclonal Antibody
SKU:
CAB6786
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 852-952 of human USP15 (NP_006304.1).
This gene encodes a member of the ubiquitin specific protease (USP) family of deubiquitinating enzymes. USP enzymes play critical roles in ubiquitin-dependent processes through polyubiquitin chain disassembly and hydrolysis of ubiquitin-substrate bonds. The encoded protein associates with the COP9 signalosome, and also plays a role in transforming growth factor beta signalling through deubiquitination of receptor-activated SMAD transcription factors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 2.
Purification Method:
Affinity purification
Gene ID:
9958
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using USP15 antibody (CAB6786) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
