The USP1 Polyclonal Antibody (CAB6785) is a valuable tool for researchers studying USP1, a protein involved in DNA repair and maintenance of genome stability. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically binding to the USP1 protein, researchers can accurately detect and analyze USP1 levels in various cell types, making it an ideal choice for studies in DNA repair mechanisms and cancer biology.USP1 is a key player in the cellular response to DNA damage, where it regulates the activity of proteins involved in DNA repair pathways.
Understanding the function and regulation of USP1 is crucial for developing targeted therapies for cancer treatment, as dysregulation of USP1 has been linked to genomic instability and tumor progression. The USP1 Polyclonal Antibody provides researchers with a reliable tool to explore the role of USP1 in DNA repair processes and its potential as a therapeutic target in cancer research.
Product Name:
USP1 Rabbit Polyclonal Antibody
SKU:
CAB6785
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human USP1 (NP_003359.3).
This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases that is a deubiquitinating enzyme (DUB) with His and Cys domains. This protein is located in the cytoplasm and cleaves the ubiquitin moiety from ubiquitin-fused precursors and ubiquitinylated proteins. The protein specifically deubiquitinates a protein in the Fanconi anemia (FA) DNA repair pathway. Alternate transcriptional splice variants have been characterized.
Purification Method:
Affinity purification
Gene ID:
7398
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using USP1 antibody (CAB6785) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
