Anti-UPK2 Antibody (CAB10813)
- SKU:
- CAB10813
- Product Type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Description
Anti-UPK2 Antibody (CAB10813)
The Uroplakin-2 Polyclonal Antibody (CAB10813) is a valuable tool for researchers studying uroplakin-2, a protein involved in the formation of urothelial plaques in the bladder. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications.Uroplakin-2 is an essential component of the urothelial barrier, helping to maintain the integrity of the bladder lining and prevent microbial infections. Dysregulation of uroplakin-2 expression has been linked to various urological disorders, making it a crucial target for investigation in both basic science and clinical research.
By detecting and quantifying uroplakin-2 in cell and tissue samples, researchers can gain insight into the mechanisms underlying bladder function and dysfunction. This antibody is a valuable tool for studies focused on bladder biology, urological diseases, and potential therapeutic interventions targeting uroplakin-2.
| Antibody Name: | Anti-UPK2 Antibody |
| Antibody SKU: | CAB10813 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 85-155 of human UPK2 (NP_006751.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | B-cell |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 85-155 of human UPK2 (NP_006751.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20'C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | ELVS VVDS GAGF TVTR LSAY QVTN LVPG TKFY ISYL VKKG TATE SSRE IPMS TLPR RNME SIGL GMAR TGG |
| Gene ID: | 7379 |
| Uniprot: | O00526 |
| Cellular Location: | Cell membrane, Single-pass type I membrane protein |
| Calculated MW: | 19kDa |
| Observed MW: | 19kDa |
| Synonyms: | UPK2, UP2, UPII |
| Background: | This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas. |
| UniProt Protein Function: | UPK2: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in regulating the assembly of the AUM. Belongs to the uroplakin-2 family. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 11q23 Cellular Component: integral to plasma membrane; apical plasma membrane; integral to endoplasmic reticulum membrane Biological Process: epithelial cell differentiation; multicellular organismal development |
| NCBI Summary: | This gene encodes one of the proteins of the highly conserved urothelium-specific integral membrane proteins of the asymmetric unit membrane which forms urothelium apical plaques in mammals. The asymmetric unit membrane is believed to strengthen the urothelium by preventing cell rupture during bladder distention. The encoded protein is expressed in the peripheral blood of bladder cancer patients with transitional cell carcinomas.[provided by RefSeq, Sep 2009] |
| UniProt Code: | O00526 |
| NCBI GenInfo Identifier: | 6707761 |
| NCBI Gene ID: | 7379 |
| NCBI Accession: | O00526.2 |
| UniProt Secondary Accession: | O00526,O00457, Q53YV0, B0YJ92, |
| UniProt Related Accession: | O00526 |
| Molecular Weight: | 184 |
| NCBI Full Name: | Uroplakin-2 |
| NCBI Synonym Full Names: | uroplakin 2 |
| NCBI Official Symbol: | UPK2Â Â |
| NCBI Official Synonym Symbols: | UP2; UPIIÂ Â |
| NCBI Protein Information: | uroplakin-2; uroplakin II |
| UniProt Protein Name: | Uroplakin-2 |
| UniProt Synonym Protein Names: | Uroplakin II; UPII |
| Protein Family: | Uroplakin |
| UniProt Gene Name: | UPK2Â Â |
| UniProt Entry Name: | UPK2_HUMAN |
 | Western blot analysis of extracts of B-cell cells, using UPK2 antibody (CAB10813) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit (RM00021). Exposure time: 40s. |
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