The Uroplakin 1B Polyclonal Antibody (CAB8157) is a valuable tool for research focused on uroplakin 1B, a protein involved in the formation of urothelial plaques in the bladder. This antibody, generated in rabbits, exhibits high specificity and sensitivity towards human samples, making it ideal for use in various experimental techniques, including Western blotting.Uroplakin 1B is a key component of urothelial plaques, which play a role in maintaining the integrity and barrier function of the bladder epithelium.
Dysregulation of uroplakin expression has been associated with bladder diseases, including bladder cancer and urinary tract infections. By targeting uroplakin 1B with this antibody, researchers can investigate its role in disease pathology and potentially identify novel therapeutic targets for bladder-related conditions.
Product Name:
UPK1B Rabbit Polyclonal Antibody
SKU:
CAB8157
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 110-230 of human UPK1B (NP_008883.2).
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene.
Purification Method:
Affinity purification
Gene ID:
7348
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UPK1B antibody (CAB8157) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
