The UROD Polyclonal Antibody (CAB5493) is a versatile tool for researchers studying uroporphyrinogen decarboxylase (UROD), an enzyme involved in the heme biosynthetic pathway. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in various applications, including Western blotting. By binding specifically to the UROD protein, this antibody allows for accurate detection and analysis in different cell types, making it an excellent choice for investigations in biochemistry and molecular biology.UROD plays a crucial role in the synthesis of heme, a vital component of hemoglobin and other essential proteins in the body. Dysregulation of UROD activity has been linked to various disorders, including porphyrias and certain types of cancer.
Research into the role of UROD can provide valuable insights into these conditions and pave the way for the development of targeted therapies.By utilizing the UROD Polyclonal Antibody (CAB5493), scientists can advance their understanding of UROD function and its implications for human health. This antibody enables precise detection of UROD levels in experimental samples, facilitating detailed investigations into heme metabolism and related pathways. Its specificity and reliability make it an indispensable tool for studies in molecular biology, biochemistry, and related fields.
Product Name:
UROD Rabbit Polyclonal Antibody
SKU:
CAB5493
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 1-367 of human UROD (NP_000365.3).
This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.
Purification Method:
Affinity purification
Gene ID:
7389
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using UROD antibody (CAB5493) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
